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Glucosamine: Osteoarthritis

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By: Sean Moloughney

Editor, Nutraceuticals World

Nutraceutical: Glucosamine

Indication: Osteoarthritis (OA)

Source: Arthritis Res Ther, February 12, 2010;12(1):R25.

Research: Thirty-six low active participants (aged 42 to 73 years) were provided with 1500 mg glucosamine sulfate per day for 6 weeks, after which they began a 12-week progressive walking program, while continuing to take glucosamine. They were randomized to walk 3 or 5 days per week and given a pedometer to monitor step counts. For both groups, step level of walking was gradually increased to 3000 steps per day during the first 6 weeks of walking, and to 6000 steps per day for the next 6 weeks. Primary outcomes included physical activity levels, physical function (self-paced step test), and the WOMAC Osteoarthritis Index for pain, stiffness and physical function.

Results: During the first 6 weeks of the study (glucosamine supplementation only), physical activity levels, physical function and total WOMAC scores improved. Between the start of the walking program (Week 6) and the final follow-up (Week 24), further improvements were seen in these outcomes, although most improvements were seen between Weeks 6 and 12. No significant differences were found between walking groups. In people with hip or knee OA, researchers feel walking a minimum of 3000 steps (30 minutes), at least 3 days per week, in combination with glucosamine sulfate, may reduce OA symptoms.

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